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Motohiro Okada Selected Research

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

11/2015Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor.
11/2013A novel prophylactic effect of furosemide treatment on autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).
2/2010[Generation of epilepsy animal model bearing a genetic abnormality identified in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) of humans].
1/2005Genetics of idiopathic epilepsies.
9/2002Genetics of epilepsy: current status and perspectives.
6/2002Genetic abnormalities underlying familial epilepsy syndromes.
1/2002Molecular genetics of human familial epilepsy syndromes.

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Motohiro Okada Research Topics

Disease

20Epilepsy (Aura)
05/2022 - 01/2002
14Schizophrenia (Dementia Praecox)
06/2022 - 06/2004
10Seizures (Absence Seizure)
01/2020 - 01/2004
9Cognitive Dysfunction
06/2022 - 01/2019
8Mood Disorders (Mood Disorder)
06/2022 - 12/2002
7Panic Disorder (Panic Attack)
01/2021 - 09/2007
7Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
11/2015 - 01/2002
5Pain (Aches)
12/2021 - 02/2007
3Pathologic Constriction (Stenosis)
04/2021 - 10/2009
3Treatment-Resistant Schizophrenia
11/2020 - 01/2019
3Alzheimer Disease (Alzheimer's Disease)
01/2019 - 10/2012
3Neuroleptic Malignant Syndrome
01/2012 - 01/2010
3Benign Neonatal Epilepsy (Benign Familial Neonatal Convulsions)
03/2009 - 09/2002
3Febrile Seizures (Febrile Seizure)
01/2005 - 06/2002
2Spinal Cord Compression
01/2022 - 05/2009
2Spinal Cord Diseases
12/2021 - 10/2017
2Lordosis
12/2021 - 10/2017
2Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
04/2021 - 01/2019
2Spondylolisthesis
01/2021 - 01/2019
2Bipolar Disorder (Manic Depressive Psychosis)
12/2020 - 10/2020
2Parkinson Disease (Parkinson's Disease)
01/2020 - 01/2014
2Absence Epilepsy (Childhood Absence Epilepsy)
11/2018 - 03/2013
2Intervertebral Disc Displacement (Herniated Disc)
05/2014 - 02/2007
2Low Back Pain (Lumbago)
05/2014 - 02/2007
2Myoclonic Epilepsies (Myoclonic Encephalopathy)
03/2014 - 09/2002
2Agoraphobia
04/2012 - 09/2007
2Channelopathies
01/2012 - 01/2002
1Central Cord Syndrome
06/2022
1Pressure Ulcer (Bedsore)
06/2022
1Pneumonia (Pneumonitis)
06/2022
1Urinary Tract Infections (Urinary Tract Infection)
06/2022
1Weight Gain
04/2022
1Ossification of Posterior Longitudinal Ligament
01/2022
1Necrosis
06/2021
1Chronic Kidney Failure (Chronic Renal Failure)
05/2021
1Anxiety Disorders (Anxiety Disorder)
01/2021
1Treatment-Resistant Depressive Disorder
12/2020
1Major Depressive Disorder (Major Depressive Disorders)
12/2020
1Myocarditis (Carditis)
11/2020
1Anhedonia
10/2020
1Pseudarthrosis (Pseudoarthrosis)
08/2020
1Nocturnal Paroxysmal Dystonia
06/2020
1Hypertrophy
01/2020
1Dyskinesias (Dyskinesia)
01/2020
1Carbon Monoxide Poisoning (Poisoning, Carbon Monoxide)
10/2019

Drug/Important Bio-Agent (IBA)

10Antipsychotic Agents (Antipsychotics)IBA
06/2022 - 10/2009
7Glutamic Acid (Glutamate)FDA Link
06/2021 - 06/2004
6Anticonvulsants (Antiepileptic Drugs)IBA
06/2021 - 12/2002
6Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
10/2020 - 01/2002
6Cholinergic ReceptorsIBA
06/2020 - 11/2008
5Connexin 43 (Connexin43)IBA
05/2022 - 03/2020
5Glutamate Receptors (Glutamate Receptor)IBA
06/2021 - 01/2019
5N-Methylaspartate (NMDA)IBA
10/2020 - 01/2019
5gamma-Aminobutyric Acid (GABA)IBA
01/2020 - 06/2002
4Ion Channels (Ion Channel)IBA
01/2012 - 01/2002
3Carbamazepine (Tegretol)FDA LinkGeneric
05/2022 - 12/2002
3Lurasidone HydrochlorideFDA Link
04/2022 - 10/2019
3Antidepressive Agents (Antidepressants)IBA
12/2020 - 01/2020
3Clozapine (Clozaril)FDA LinkGeneric
11/2020 - 01/2019
3Zonisamide (Zonegran)FDA LinkGeneric
01/2020 - 12/2002
3Proteins (Proteins, Gene)FDA Link
10/2012 - 01/2012
3Serotonin (5 Hydroxytryptamine)IBA
04/2012 - 02/2007
2serotonin 7 receptorIBA
04/2022 - 10/2019
2AcidsIBA
06/2021 - 02/2007
2alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
06/2021 - 07/2019
2Guanfacine (Tenex)FDA LinkGeneric
04/2021 - 01/2019
2Adrenergic Receptors (Adrenergic Receptor)IBA
04/2021 - 01/2019
2Levodopa (L Dopa)FDA LinkGeneric
01/2020 - 01/2014
2Memantine (Namenda)FDA Link
01/2019 - 01/2019
2Brain-Derived Neurotrophic Factor (BDNF)IBA
06/2014 - 01/2014
2Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
01/2014 - 03/2009
2Messenger RNA (mRNA)IBA
11/2013 - 06/2005
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
03/2012 - 06/2004
2GABA Receptors (GABA Receptor)IBA
06/2010 - 09/2002
2Pharmaceutical PreparationsIBA
10/2009 - 09/2007
2Neurotransmitter Agents (Neurotransmitter)IBA
10/2009 - 06/2005
2Hemoglobins (Hemoglobin)IBA
03/2009 - 09/2007
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
10/2021
1brivaracetamIBA
06/2021
1ThrombinFDA Link
04/2021
1GelatinIBA
04/2021
1Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
01/2021
1EsketamineIBA
12/2020
1ConnexinsIBA
12/2020
1KetamineFDA LinkGeneric
10/2020
1Oxidopamine (6 Hydroxydopamine)IBA
01/2020
1BicucullineIBA
01/2020
1MuscimolIBA
01/2020
1Dihydroxyphenylalanine (Dopa)IBA
01/2020

Therapy/Procedure

8Decompression
01/2022 - 10/2009
4Laminectomy
01/2022 - 10/2017
3Laminoplasty
12/2021 - 05/2009
2Spinal Fusion (Spondylosyndesis)
08/2020 - 10/2010
1Length of Stay
06/2022
1Kidney Transplantation
05/2021
1Renal Replacement Therapy (Therapies, Renal Replacement)
05/2021
1Pedicle Screws
01/2021
1Drug Therapy (Chemotherapy)
12/2020
1Pallidotomy
01/2020
1Deep Brain Stimulation
01/2020